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Ozempic and Wegovy are brand names for semaglutide. It is a long-acting GLP-1 agonist that can be administered subcutaneously once a week.

It has been shown to be effective for weight loss in trials involving patients with and without type 2 diabetes. In fact, Ozempic was developed to treat type 2 diabetes because it helps lower blood sugar.

But this ended up having a secondary weight loss benefit, which then carried over when people without type 2 diabetes began ordering Ozempic to help them lose weight.

Keep in mind that only the injectable form, Wegovy, is approved for the treatment of obesity (not the oral version).

Semglutide has also been shown to reduce cardiovascular (CV) risk factors in patients with established cardiovascular disease in some cardiovascular outcomes trials.

How does Ozempic work for weight loss?

Once considered overweight or obese, treatment is as follows: Ozempic injections at the maximum dose (2.4 mg per week) achieve maximum weight loss.

But patients should not start with the maximum dose right away, as some cannot tolerate the dose and may experience side effects, such as nausea or vomiting. Therefore, a gradual increase in dose is recommended.

The way semaglutide (Ozempic and Wegovy) works for weight loss is quite interesting. GLP-1 is a major incretin hormone in humans. In other words, it increases the insulin section, inhibits glucagon release, and suppresses hepatic gluconeogenesis.

Semaglutide also causes delayed gastric emptying, reduced appetite and energy intake, which is why it has beneficial effects on weight loss. It reduces the speed at which your stomach empties food after a meal (gastric emptying). The longer gastric emptying takes, the longer food stays in your stomach, allowing you to feel full for longer.

This results in reduced hunger and appetite. Overall, patients taking Ozempic or Wegovy end up eating less food and therefore losing weight.

Ozempic not only affects gastric emptying, but also the GLP-1 receptors present in the hypothalamus, which are responsible for regulating food intake in the nervous system. This reduces the feeling of hunger and appetite in obese people.

In addition, GLP-1 also affects the receptors responsible for satiety in the brain. It stimulates these specific